Solutions Case Studies
Download DocumentMDL® Assay Explorer® goes to school
Application of MDL informatics and workflow tools in an academic high-throughput screening lab
Researchers at Stanford School of Medicine's High-Throughput Bioscience Center (HTBC) have recently used an MDL® Select suite of informatics and experiment management tools to screen Renal Cell Carcinoma (RCC) cell lines for sensitivity to a series of compounds.
The project involved the parallel screening of RCC cell lines (matched for VHL expression) for sensitivity to a series of compounds. Hypothesizing that the difference in transcriptional states between VHL-deficient and VHL-positive cells could be exploited for a positive therapeutic response, researchers developed a robust cellular assay and screened 64,000 compounds in 384-well plates.
The primary workhorse for managing the biological aspects of high-throughput screening is the MDL® Assay Explorer® biological data management system. Assay Explorer captures, analyzes and stores experimental results and provides functionality that enables researchers to select actives, remove outliers, validate data and identify trends.
For more information on Stanford's High-Throughput Bioscience Center, please visit http://htbc.stanford.edu.
To read the complete case study, click the Download Document link near the top of the this article.
